Space is the use of an entire medium, in a image it's the use of a page, in it's the actual piece and the surroundings. in this piece it uses the negative space or the blank parts to create the illusion of full shapes, split in half
This piece of line art is pretty creative. The artist has done a wonderful job taking a design and making it have a effect. The position of the hole on the rule of thirds line gives the design some depth and still keeps the symmetry.