The picture illustrates how Macbeth had to kill for his kingship. And how Macbeth killed everyone even people like Macduff's family who had no effect on his kingship. Macbeth killed many people in the play and this is a funny meme to illustrate that.
'Out, damned spot! - One: two: why, then, 'tis time to do't. - Hell is murky!' - Macbeth act scene This picture illustrates how Lady Macbeth feels when she gets the hallucinations associated with her mental illness.
Life’s but a walking shadow, a poor player That struts and frets his hour upon the stage And then is heard no more. It’s a tale Told by an idiot, full of sound and fury, Signifying nothing. [William Shakespeare - from Macbeth Act Scene